Restore Calm Sleep And Anxiety Capsules Bioceuticals Restore Calm Sleep And Anxiety Capsule RestoraCalm is contraindicated in pregnancy and lactation due to the berberine content ofPhellodendron amurense, and lack of relevant evidence available for Magnolia officinalis. There is insufficient research to recommend the use of RestoraCalm in children. There are no known drug interactions with RestoraCalm; however, Magnolia officinalis bark extract may theoretically potentiate the central depressant effects of other agents that have sedative properties such as alcohol, barbiturates, benzodiazepines and other central nervous system (CNS) depressants. There is preliminary evidence that berberine, a constituent of Phellodendron amurense, may inhibit cytochrome P450 3A4 (CYP3A4) enzymes; however, this interaction is yet to be reported in humans.